Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Understanding the mechanisms by which chromatin structure controls eukaryotic
transcription has been an intense area of investigation for the past 25 years. Many of the key …

We present the first complete high-resolution map of nucleosome occupancy across the
whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned nucleosomes …

Previous studies indicate that eukaryotic promoters display a stereotypical chromatin
landscape characterized by a well-positioned+ 1 nucleosome near the transcription start site …

Packaging of eukaryotic genomes into chromatin affects every process that occurs on DNA.
The positioning of nucleosomes on underlying DNA plays a key role in the regulation of …

Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …

Nucleosomes present a barrier for the binding of most transcription factors (TFs). However,
special TFs known as nucleosome-displacing factors (NDFs) can access embedded sites …

Background Growth rate is central to the development of cells in all organisms. However,
little is known about the impact of changing growth rates. We used continuous cultures to …

Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …

The DNA of eukaryotic cells is spooled around large histone protein complexes, forming
nucleosomes that make up the basis for a high-order packaging structure called chromatin …