[HTML][HTML] Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies
Promotion of good mental health, prevention, and early intervention before/at the onset of
mental disorders improve outcomes. However, the range and peak ages at onset for mental …
mental disorders improve outcomes. However, the range and peak ages at onset for mental …
The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Genetics and genomics of psychiatric disease
DH Geschwind, J Flint - Science, 2015 - science.org
Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …
Convergence of placenta biology and genetic risk for schizophrenia
Defining the environmental context in which genes enhance disease susceptibility can
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …
provide insight into the pathogenesis of complex disorders. We report that the intra-uterine …
Neurodevelopmental model of schizophrenia: update 2012
JL Rapoport, JN Giedd, N Gogtay - Molecular psychiatry, 2012 - nature.com
The neurodevelopmental model of schizophrenia, which posits that the illness is the end
state of abnormal neurodevelopmental processes that started years before the illness onset …
state of abnormal neurodevelopmental processes that started years before the illness onset …
[HTML][HTML] CNVs: harbingers of a rare variant revolution in psychiatric genetics
D Malhotra, J Sebat - Cell, 2012 - cell.com
The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry.
Genome-wide studies of copy number variation (CNV) have given rise to a new …
Genome-wide studies of copy number variation (CNV) have given rise to a new …
[HTML][HTML] De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia
G Kirov, AJ Pocklington, P Holmans, D Ivanov… - Molecular …, 2012 - nature.com
A small number of rare, recurrent genomic copy number variants (CNVs) are known to
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity …
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity …
Comorbidity clusters in autism spectrum disorders: an electronic health record time-series analysis
OBJECTIVE: The distinct trajectories of patients with autism spectrum disorders (ASDs) have
not been extensively studied, particularly regarding clinical manifestations beyond the …
not been extensively studied, particularly regarding clinical manifestations beyond the …
[HTML][HTML] The co-morbidity burden of children and young adults with autism spectrum disorders
Objectives Use electronic health records Autism Spectrum Disorder (ASD) to assess the
comorbidity burden of ASD in children and young adults. Study Design A retrospective …
comorbidity burden of ASD in children and young adults. Study Design A retrospective …
Analysis of copy number variations at 15 schizophrenia-associated loci
E Rees, JTR Walters, L Georgieva, AR Isles… - The British Journal of …, 2014 - cambridge.org
BackgroundA number of copy number variants (CNVs) have been suggested as
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …
susceptibility factors for schizophrenia. For some of these the data remain equivocal, and the …