HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Role of nuclear progesterone receptor isoforms in uterine pathophysiology

B Patel, S Elguero, S Thakore… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

The immunosuppressive molecule HLA-G and its clinical implications

Á González, V Rebmann, J LeMaoult… - Critical reviews in …, 2012 - Taylor & Francis
Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex
(MHC) class I molecule that, through interaction with its receptors, exerts important …

Transcriptional and Posttranscriptional Regulations of the HLA-G Gene

EC Castelli, LC Veiga-Castelli, L Yaghi… - Journal of …, 2014 - Wiley Online Library
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-
G coding region has been maintained during the evolution process, in which most of its …

HLA‐G as a tolerogenic molecule in transplantation and pregnancy

V Rebmann, F da Silva Nardi… - Journal of …, 2014 - Wiley Online Library
HLA‐G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or
allograft transplantation, the expression of HLA‐G has been related to a better acceptance of …

HLA-G neo-expression on tumors

M Loustau, F Anna, R Dréan, M Lecomte… - Frontiers in …, 2020 - frontiersin.org
HLA-G is known to modulate the immune system activity in tissues where physiological
immune-tolerance is necessary (ie, maternal-fetal interface, thymus, and cornea). However …

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

I Tirado-Gonzalez, N Freitag… - MHR: Basic science …, 2012 - academic.oup.com
Abstract Galectin-1 (gal-1) is expressed at the feto-maternal interface and plays a role in
regulating the maternal immune response against placental alloantigens, contributing to …

HLA-G genotype/expression/disease association studies: success, hurdles, and perspectives

G Amodio, S Gregori - Frontiers in Immunology, 2020 - frontiersin.org
The non-classical HLA-G is a well-known immune-modulatory molecule. In physiological
condition, HLA-G surface expression is restricted to the maternal–fetal interface and to …

HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro

X He, D Dong, S Yie, H Yang, M Cao, S Ye, K Li… - Annals of surgical …, 2010 - Springer
Objective The aim of this study is to investigate clinical implications of human leukocyte
antigen-G (HLA-G) expression in breast cancer. Methods HLA-G expression in 235 primary …

The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

R Rizzo, M Vercammen, H Van De Velde… - Cellular and molecular …, 2011 - Springer
The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every
pregnancy. It differs from classical HLA class I molecules by the low degree of allelic variants …