A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Purpose—Our goal is to provide an overview of the current evidence about components of
the evaluation and treatment of adults with acute ischemic stroke. The intended audience is …

Background and Purpose—The authors present an overview of the current evidence and
management recommendations for evaluation and treatment of adults with acute ischemic …

Reactive oxygen species and oxidative state are slowly gaining acceptance in having a
physiological relevance rather than just being the culprits in pathophysiological processes …

Background and Purpose—After large-vessel intracranial occlusion, the fate of the ischemic
penumbra, and ultimately final infarct volume, largely depends on tissue perfusion. In this …

The goal of acute stroke treatment with intravenous thrombolysis or endovascular
recanalization techniques is to rescue the penumbral tissue. Therefore, knowing the factors …

We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …

Brain injury after focal ischemia evolves along two basically different pathophysiologies,
depending on the severity of the primary flow reduction and the dynamics of postischemic …

The global burden of stroke remains high, and of the various subtypes of stroke, large vessel
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …

Objective: Cerebral perfusion imaging with computed tomography (CT) or magnetic
resonance (MR) is widely available. The optimum perfusion values to identify tissue at risk of …