A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

During the last decades, lipids have gained much attention due to their involvement in
health and disease. Lipids are required for the formation of membranes and contribute to …

Ergosterol, an important component of the fungal cell membrane, is not only essential for
fungal growth and development but also very important for adaptation to stress in fungi …

Summary Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis,
believed to drive sterol integration into the lysosomal membrane before redistribution to …

Dehydrocholesterol (7-DHC) is widely present in various organisms and is an important
precursor of vitamin D 3. Despite significant improvements in the biosynthesis of 7-DHC, it …

Sterol homeostasis is essential for the function of cellular membranes and requires feedback
inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the …

Mitochondria are partially autonomous organelles that depend on the import of certain
proteins and lipids to maintain cell survival and membrane formation. Although …

We investigated the impact of the deletions of genes from the final steps in the biosynthesis
of ergosterol (ERG6, ERG2, ERG3, ERG5, ERG4) on the physiological function of the …

Sterols are crucial functional components for eukaryotic cell membrane. Due to versatile
activities, sterols show wide applications in food and pharmaceutical industries. Ergosterol …

Sterols and related membrane-perturbing agents are subject to a quality control cycle.
Compounds that fail to pass this control are acetylated and secreted into the culture media …