Hepatic encephalopathy: definition, clinical grading and diagnostic principles

K Weissenborn - Drugs, 2019 - Springer
In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver
insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type …

the design of clinical trials in hepatic encephalopathy–an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement

JS Bajaj, J Cordoba, KD Mullen… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 33: 739–747 Summary Background The clinical classification
of hepatic encephalopathy is largely subjective, which has led to difficulties in designing …

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy

S Montagnese, PE Rautou, M Romero-Gómez… - Journal of …, 2022 - Elsevier
Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …

Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: a randomized controlled trial

Y Lv, H Chen, B Luo, W Bai, K Li, Z Wang, D Xia… - …, 2022 - Wiley Online Library
Abstract Background and Aims Large spontaneous portosystemic shunt (SPSS) is
associated with increased risk of HE in patients undergoing transjugular intrahepatic …

Association between portosystemic shunts and increased complications and mortality in patients with cirrhosis

M Simón-Talero, D Roccarina, J Martínez… - Gastroenterology, 2018 - Elsevier
Background & Aims Spontaneous portosystemic shunts (SPSS) have been associated with
hepatic encephalopathy (HE). Little is known about their prevalence among patients with …

[PDF][PDF] Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: a multicenter survey on safety and efficacy

W Laleman, M Simon‐Talero, G Maleux, M Perez… - …, 2013 - Wiley Online Library
Refractory hepatic encephalopathy (HE) remains a major cause of morbidity in cirrhosis
patients. Large spontaneous portosystemic shunts (SPSSs) have been previously …

[HTML][HTML] Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

M Praktiknjo, M Simón-Talero, J Römer… - Journal of …, 2020 - Elsevier
Background & Aims Spontaneous portosystemic shunts (SPSS) frequently develop in liver
cirrhosis. Recent data suggested that the presence of a single large SPSS is associated with …

Notch‐triggered maladaptation of liver sinusoidal endothelium aggravates nonalcoholic steatohepatitis through endothelial nitric oxide synthase

ZQ Fang, B Ruan, JJ Liu, JL Duan, ZS Yue… - …, 2022 - Wiley Online Library
Abstract Background and Aims Although NASH can lead to severe clinical consequences,
including cirrhosis and hepatocellular carcinoma, no effective treatment is currently …

The modern management of hepatic encephalopathy

JS Bajaj - Alimentary pharmacology & therapeutics, 2010 - Wiley Online Library
Aliment Pharmacol Ther 31, 537–547 Summary Background Hepatic encephalopathy, both
overt and minimal, forms a continuum of cognitive change in cirrhosis. Strategies to …

[HTML][HTML] Hepatic encephalopathy: an update on the pathophysiology and therapeutic options

S Elwir, RS Rahimi - Journal of clinical and translational …, 2017 - ncbi.nlm.nih.gov
Hepatic encephalopathy is a spectrum of reversible neuropsychiatric abnormalities, seen in
patients with liver dysfunction and/or portosystemic shunting. One of the most debilitating …