Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Synaptic loss is the cardinal feature linking neuropathology to cognitive decline in
Alzheimer's disease (AD). However, the mechanism of synaptic damage remains …

Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and
depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight …

Two primary animal models persist for assessing hallucinogenic potential of novel
compounds and for examining the pharmacological and neurobiological substrates …

D 1 dopamine receptors are primary mediators of dopaminergic signaling in the CNS. These
receptors internalize rapidly following agonist-induced activation, but the functional …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Obsessive-compulsive disorder (OCD) affects 2%–3% of the population worldwide and can
cause significant distress and disability. Substantial challenges remain in the field of OCD …

It is often suggested that stereotypic behaviour represents a coping response to suboptimal
environmental conditions. However, individuals of many species show different coping …

Psychosocial stress is a major risk factor for depression, stress leads to peripheral and
central immune activation, immune activation is associated with blunted dopamine (DA) …