Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …

Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the
gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (GIPR) on β …

Paracrine interactions between pancreatic islet cells have been proposed as a mechanism
to regulate hormone secretion and glucose homeostasis. Here, we demonstrate the …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

The islet of Langerhans is a complex endocrine micro-organ consisting of a multitude of
endocrine and non-endocrine cell types. The two most abundant and prominent endocrine …