Metallodrugs are unique: Opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Recent advances in endoplasmic reticulum targeting metal complexes
Over the last few years, significant attention has been paid to develop metal complexes for
different cellular organelle specific imaging agents and to achieve organelle targeting …
different cellular organelle specific imaging agents and to achieve organelle targeting …
Mechanistic roles of metal-and ligand-protonated species in hydrogen evolution with [Cp* Rh] complexes
Protonation reactions involving organometallic complexes are ubiquitous in redox chemistry
and often result in the generation of reactive metal hydrides. However, some organometallic …
and often result in the generation of reactive metal hydrides. However, some organometallic …
Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility
Organometallic compounds based on bioactive ligand systems have shown promising
antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive …
antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive …
Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper (II) Complexes: the Role of Key Structural Components and …
I Kuznetcova, F Bacher, SM Alfadul… - Inorganic …, 2022 - ACS Publications
Indolo [3, 2-d][1] benzazepines (paullones), indolo [3, 2-d][2] benzazepines, and indolo [2, 3-
d][2] benzazepines (latonduines) are isomeric scaffolds of current medicinal interest. Herein …
d][2] benzazepines (latonduines) are isomeric scaffolds of current medicinal interest. Herein …
Identification of anti-cancer organometallic compounds by inhibition of BCL-2/Bax interactions
M Afzal, A Alarifi, NAY Abduh, A Ayub… - Computers in Biology …, 2023 - Elsevier
Apoptosis is regulated by the BCL-2 family, which includes the anti-apoptotic and pro-
apoptotic proteins (Bax, Bok, Bak, etc.). These proteins often interact in dimers and act as …
apoptotic proteins (Bax, Bok, Bak, etc.). These proteins often interact in dimers and act as …
Half-Sandwich Cyclometalated RhIII Complexes Bearing Thiolate Ligands: Biomolecular Interactions and In Vitro and In Vivo Evaluations
A Nahaei, Z Mandegani, S Chamyani… - Inorganic …, 2022 - ACS Publications
A class of cyclometalated RhIII complexes [Cp* Rh (ppy)(SR)] bearing thiolate ligands, Cp*=
pentamethylcyclopentadienyl, ppy= 2-phenylpyridinate, and R= pyridyl (Spy, 2), pyrimidyl …
pentamethylcyclopentadienyl, ppy= 2-phenylpyridinate, and R= pyridyl (Spy, 2), pyrimidyl …
Cell nucleus localization and high anticancer activity of quinoline–benzopyran rhodium (III) metal complexes as therapeutic and fluorescence imaging agents
ZF Wang, XL Nai, Y Xu, FH Pan, FS Tang, QP Qin… - Dalton …, 2022 - pubs.rsc.org
Four novel rhodium (III) complexes,[RhIII (QB1) Cl3 (DMSO)](RhN1),[RhIII (QB2) Cl3
(CH3OH)]· CH3OH (RhN2),[RhIII (QB3) Cl3 (CH3OH)]· CH3OH (RhS), and [RhIII (QB4) Cl3 …
(CH3OH)]· CH3OH (RhN2),[RhIII (QB3) Cl3 (CH3OH)]· CH3OH (RhS), and [RhIII (QB4) Cl3 …
Activation of H–H, HO–H, C(sp2)–H, C(sp3)–H, and RO–H Bonds by Transition-Metal Frustrated Lewis Pairs Based on M/N (M = Rh, Ir) Couples
M Carmona, R Pérez, J Ferrer, R Rodríguez… - Inorganic …, 2022 - ACS Publications
Reaction of the dimers [(Cp* MCl) 2 (μ-Cl) 2](Cp*= η5-C5Me5) with Ph2PCH2CH2NC (NH
(p-Tolyl)) 2 (H2L) in the presence of NaSbF6 affords the chlorido complexes [Cp* MCl (κ2 N …
(p-Tolyl)) 2 (H2L) in the presence of NaSbF6 affords the chlorido complexes [Cp* MCl (κ2 N …
Host–Guest Interactions of Ruthenium (II) Arene Complexes with Cucurbit [7/8] uril
E Roth, RV Listyarini, TS Hofer… - Inorganic Chemistry, 2024 - ACS Publications
Cucurbit [n] urils (CB [n] s) have been recognized for their chemical and thermal stability,
and their ability to bind many neutral and cationic guest molecules makes them excellent …
and their ability to bind many neutral and cationic guest molecules makes them excellent …