A survey of Monte Carlo methods for parameter estimation
Statistical signal processing applications usually require the estimation of some parameters
of interest given a set of observed data. These estimates are typically obtained either by …
of interest given a set of observed data. These estimates are typically obtained either by …
Use of randomized sampling for analysis of metabolic networks
J Schellenberger, BØ Palsson - Journal of biological chemistry, 2009 - ASBMB
Genome-scale metabolic network reconstructions in microorganisms have been formulated
and studied for about 8 years. The constraint-based approach has shown great promise in …
and studied for about 8 years. The constraint-based approach has shown great promise in …
[图书][B] Computational statistics
GH Givens, JA Hoeting - 2012 - books.google.com
This new edition continues to serve as a comprehensive guide to modern and classical
methods of statistical computing. The book is comprised of four main parts spanning the …
methods of statistical computing. The book is comprised of four main parts spanning the …
Multidimensional optimality of microbial metabolism
Although the network topology of metabolism is well known, understanding the principles
that govern the distribution of fluxes through metabolism lags behind. Experimentally, these …
that govern the distribution of fluxes through metabolism lags behind. Experimentally, these …
[图书][B] Monte Carlo methods in Bayesian computation
Sampling from the posterior distribution and computing posterior quanti ties of interest using
Markov chain Monte Carlo (MCMC) samples are two major challenges involved in advanced …
Markov chain Monte Carlo (MCMC) samples are two major challenges involved in advanced …
Stable diverse food webs become more common when interactions are more biologically constrained
Ecologists have long sought to understand how diversity and structure mediate the stability
of whole ecosystems. For high-diversity food webs, the interactions between species are …
of whole ecosystems. For high-diversity food webs, the interactions between species are …
An upper limit on Gibbs energy dissipation governs cellular metabolism
B Niebel, S Leupold, M Heinemann - Nature Metabolism, 2019 - nature.com
The principles governing cellular metabolic operation are poorly understood. Because
diverse organisms show similar metabolic flux patterns, we hypothesized that a fundamental …
diverse organisms show similar metabolic flux patterns, we hypothesized that a fundamental …
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
Metabolic coupling of Mycobacterium tuberculosis to its host is foundational to its
pathogenesis. Computational genome‐scale metabolic models have shown utility in …
pathogenesis. Computational genome‐scale metabolic models have shown utility in …
Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect
The Warburg effect-a classical hallmark of cancer metabolism-is a counter-intuitive
phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production …
phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production …
Flux sampling is a powerful tool to study metabolism under changing environmental conditions
HA Herrmann, BC Dyson, L Vass… - NPJ systems biology …, 2019 - nature.com
The development of high-throughput 'omic techniques has sparked a rising interest in
genome-scale metabolic models, with applications ranging from disease diagnostics to crop …
genome-scale metabolic models, with applications ranging from disease diagnostics to crop …