Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that
inhibit the entry of a wide range of clinically important pathogens including influenza A virus …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of
deaths since its emergence in 2019. Innate immune antagonism by lethal CoVs such as …

Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …

DNA sensing is a pivotal component of the innate immune system that is responsible for
detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the …

Abstract Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive
roles in cancer. There is clinical success of targeting this complex in PRC2-dependent …

Somatic mutations in DNA methyltransferase 3A (DNMT3A) are among the most frequent
alterations in clonal hematopoiesis (CH) and acute myeloid leukemia (AML), with a hotspot …