Recent developments and current controversies in depression

KP Ebmeier, C Donaghey, JD Steele - The Lancet, 2006 - thelancet.com
In this review of the last 5 years' developments in research into depression we focus on
recent advances and current controversies. We cover epidemiology and basic science as …

The role of monoamine oxidase enzymes in the pathophysiology of neurological disorders

DN Jones, MA Raghanti - Journal of Chemical Neuroanatomy, 2021 - Elsevier
Monoamine oxidase enzymes are responsible for the degredation of serotonin, dopamine,
and norepinephrine in the central neurvous system. Although it has been nearly 100 years …

Poor replication of candidate genes for major depressive disorder using genome-wide association data

FJ Bosker, CA Hartman, IM Nolte, BP Prins… - Molecular …, 2011 - nature.com
Abstract Data from the Genetic Association Information Network (GAIN) genome-wide
association study (GWAS) in major depressive disorder (MDD) were used to explore …

Gene–environment interaction analysis of serotonin system markers with adolescent depression

TC Eley, K Sugden, A Corsico, AM Gregory… - Molecular …, 2004 - nature.com
We report analyses from a study of gene–environment interaction in adolescent depression.
The sample was selected from 1990 adolescents aged 10–20 years: those with depression …

Meta-analyses of genetic studies on major depressive disorder

S López-León, A Janssens… - Molecular …, 2008 - nature.com
The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …

Impulsivity, aggression, and serotonin: a molecular psychobiological perspective

KP Lesch, U Merschdorf - Behavioral sciences & the law, 2000 - Wiley Online Library
The expression of aggressiveness, which constitutes many facets of behavior, is influenced
by a complex interaction of biologic, psychologic, and social variables. Even though …

An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences

Y Huang, SP Cate, C Battistuzzi, MA Oquendo… - …, 2004 - nature.com
Monoamine oxidase A (MAOA) activity is altered in mood disorders and lower activity
associated with aggressive behavior. The gene has a functional polymorphism with a …

ADHD co-morbidities: A review of implication of gene× environment effects with dopamine-related genes

M Kanarik, O Grimm, NR Mota, A Reif… - … & Biobehavioral Reviews, 2022 - Elsevier
ADHD is a major burden in adulthood, where co-morbid conditions such as depression,
substance use disorder and obesity often dominate the clinical picture. ADHD has …

Toward a molecular architecture of personality

A Reif, KP Lesch - Behavioural brain research, 2003 - Elsevier
Epidemiological studies provided a large body of evidence that personality dimensions are
influenced by genetic factors and that the genetic component is highly complex, polygenic …

Reduced amygdala–prefrontal coupling in major depression: association with MAOA genotype and illness severity

U Dannlowski, P Ohrmann, C Konrad… - International Journal …, 2009 - academic.oup.com
The amygdala plays a pivotal role in a cortico-limbic circuitry implicated in emotion
processing and regulation. In the present study, functional connectivity of the amygdala with …