Therapeutic developments targeting acute myeloid leukemia (AML) have been in the
pipeline for five decades and have recently resulted in the approval of multiple targeted …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

Bruton's tyrosine kinase (BTK) plays a key role in the B-cell receptor (BCR) signaling
pathway and confers anti-apoptotic and proliferative properties to malignant B-cells in …

Mitochondrial glycolysis and hyperactivity of the phosphatidylinositol 3‐kinase–protein
kinase B (AKT) pathway are hallmarks of malignant brain tumors. However, kinase inhibitors …

Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …

Cancer is a major public health problem worldwide with more than an estimated 19.3 million
new cases in 2020. The occurrence rises dramatically with age, and the overall risk …

The hypoxic environment within a solid tumor is a limitation to the effectiveness of
photodynamic therapy. Here, we demonstrate the use of oxygen generating nanozymes …

In this research, two homo-dinuclear Cu (II)(1) and Co (II)(2) complex with an “end-off”
compartmental Schiff base ligand 2, 6-bis {3-(dimethylamino)-propyliminomethyl}-4 …

In molecular pathology, predictive biomarkers identify which patients are likely to respond to
targeted drugs. These therapeutic agents block specific molecules directly involved in …

Simple Summary Human papillomavirus positive tonsillar and base of tongue cancers are
rising in incidence but chemoradiotherapy has not improved survival, so novel treatments …