Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely
important in the regulation of the recruitment and activity of many signaling proteins in …

Among the cellular lipids, phosphatidic acid (PA) is a peculiar one as it is at the same time a
key building block of phospholipid synthesis and a major lipid second messenger conveying …

Pancreatic β-cells possess an inherent ability to generate oscillatory signals that trigger
insulin release. Coordination of the secretory activity among β-cells results in pulsatile …

Substantial efforts have recently been made to demonstrate the importance of lipids and
lipid-modifying enzymes in various membrane trafficking processes, including calcium …

Extracellular vesicles released by viable cells (exosomes and microvesicles) have emerged
as important organelles supporting cell-cell communication. Because of their potential …

Phosphoinositides are essential signaling molecules linked to a diverse array of cellular
processes in eukaryotic cells. The metabolic interconversions of these phospholipids are …

The regulated secretory pathway in neuroendocrine cells ends with the release of hormones
and neurotransmitters following a rise in cytosolic calcium. This process known as regulated …

Inositol pyrophosphates, also designated inositol diphosphates, possess high-energy β-
phosphates that can pyrophosphorylate proteins and regulate various cellular processes …

Abstract A role for phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P 2) in membrane fusion
was originally identified for regulated dense-core vesicle exocytosis in neuroendocrine cells …