Eukaryotic ribosome assembly

J Baßler, E Hurt - Annual review of biochemistry, 2019 - annualreviews.org
Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

Ribosome biogenesis and cancer: overview on ribosomal proteins

A Pecoraro, M Pagano, G Russo, A Russo - International journal of …, 2021 - mdpi.com
Cytosolic ribosomes (cytoribosomes) are macromolecular ribonucleoprotein complexes that
are assembled from ribosomal RNA and ribosomal proteins, which are essential for protein …

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

KE Bohnsack, MT Bohnsack - The EMBO journal, 2019 - embopress.org
The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

A puzzle of life: crafting ribosomal subunits

D Kressler, E Hurt, J Baßler - Trends in biochemical sciences, 2017 - cell.com
The biogenesis of eukaryotic ribosomes is a complicated process during which the
transcription, modification, folding, and processing of the rRNA is coupled with the ordered …

How ribosomes translate cancer

SO Sulima, IJF Hofman, K De Keersmaecker… - Cancer discovery, 2017 - AACR
A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and
somatic ribosomal mutations in various cancers, have significantly increased our …

Rare ribosomopathies: insights into mechanisms of cancer

A Aspesi, SR Ellis - Nature Reviews Cancer, 2019 - nature.com
Long thought to be too big and too ubiquitous to fail, we now know that human cells can fail
to make sufficient amounts of ribosomes, causing a number of diseases collectively known …

Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2–p53 pathways

NM Castillo Duque de Estrada, M Thoms… - Nature Structural & …, 2023 - nature.com
The 5S ribonucleoprotein (RNP) is assembled from its three components (5S rRNA,
Rpl5/uL18 and Rpl11/uL5) before being incorporated into the pre-60S subunit. However …

Ribosomal biogenesis as an emerging target of neurodevelopmental pathologies

M Hetman, LP Slomnicki - Journal of neurochemistry, 2019 - Wiley Online Library
Abstract Development of the nervous system is carried out by complex gene expression
programs that are regulated at both transcriptional and translational level. In addition, quality …

The ribosome,(slow) beating heart of cancer (stem) cell

A Bastide, A David - Oncogenesis, 2018 - nature.com
The ribosome has long been considered as a consistent molecular factory, with a rather
passive role in the translation process. Recent findings have shifted this obsolete view …

Stress response and tolerance mechanisms of ammonia exposure based on transcriptomics and metabolomics in Litopenaeus vannamei

J Xiao, QY Li, JP Tu, XL Chen, XH Chen, QY Liu… - Ecotoxicology and …, 2019 - Elsevier
Ammonia, one of the major limiting environment factors in aquaculture, may pose a threat to
the shrimp growth, reproduction and survival. In this study, to understand molecular …