Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy
of therapeutic antibodies. While the biantennary complex-type oligosaccharide attached to …

Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …

Distinct genes encode 6 human receptors for IgG (hFcγRs), 3 of which have 2 or 3
polymorphic variants. The specificity and affinity of individual hFcγRs for the 4 human IgG …

Mouse IgG subclasses display a hierarchy of in vivo activities, with IgG2a and IgG2b
showing the greatest protective and pathogenic properties. These enhanced activities result …

The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

Ig-like transcript 4 (ILT4)(also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is
a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also …

2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …

Depletion of fucose from human IgG1 oligosaccharide improves its affinity for Fcγ receptor
IIIa (FcγRIIIa). This is the first case where a glycoform modification is shown to improve …

The contribution of Fc-mediated effector functions to the therapeutic efficacy of some
monoclonal antibodies has motivated efforts to enhance interactions with Fcγ receptors …

2005-09-29 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAYES, ROBERT …