Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Vaccines are among the most impactful public health interventions, preventing millions of
new infections and deaths annually worldwide. However, emerging data suggest that …

Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

The complement system plays a critical role in innate immune defense against pathogens,
both via non-specific direct pathogen recognition and killing or via antigen-specific indirect …

Differentiation of naïve CD4+ T cells into functionally distinct T helper (TH) subsets is crucial
for the orchestration of immune responses. Because of extensive heterogeneity and multiple …

Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of
immunologically privileged erythrocytes provides a relatively protective niche as well as …

IgG3 comprises only a minor fraction of IgG and has remained relatively understudied until
recent years. Key physiochemical characteristics of IgG3 include an elongated hinge region …

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory tract
infection and death in young infants and the elderly. With no effective prophylactic treatment …

Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of
repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …