Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Methods to functionalize arenes and heteroarenes in a site-selective manner are highly
sought after for rapidly constructing value-added molecules of medicinal, agrochemical, and …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

The heterocycles are the versatile compounds existing in almost all natural products and
synthetic organic compounds, usually associated with one or the other biological activity …

Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

The crisis currently facing antibacterial chemotherapy threatens to return our treatment of
bacterial infections to the so-called 'dark age'of a preantibiotic era with the alarming …

Over the course of the past half century, the structural elucidation of unknown natural
products has undergone a tremendous revolution. Before World War II, a chemist would …

A literature survey covering more than twenty-three thousand bioactive microbial products
including eight thousand antiinfectives demonstrated the increasing relevance of the so …