Viral respiratory pathogens and lung injury

N Clementi, S Ghosh, M De Santis… - Clinical microbiology …, 2021 - Am Soc Microbiol
Several viruses target the human respiratory tract, causing different clinical manifestations
spanning from mild upper airway involvement to life-threatening acute respiratory distress …

Current in vivo models of varicella-zoster virus neurotropism

R Mahalingam, A Gershon, M Gershon, JI Cohen… - Viruses, 2019 - mdpi.com
Varicella-zoster virus (VZV), an exclusively human herpesvirus, causes chickenpox and
establishes a latent infection in ganglia, reactivating decades later to produce zoster and …

Varicella virus-host interactions during latency and reactivation: lessons from simian varicella virus

O Sorel, I Messaoudi - Frontiers in microbiology, 2018 - frontiersin.org
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus and the causative agent of
varicella (chickenpox) in humans. Following primary infection, VZV establishes latency in the …

Transcriptional and functional remodeling of lung-resident T cells and macrophages by Simian varicella virus infection

BM Doratt, DC Malherbe, I Messaoudi - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Varicella zoster virus (VZV) causes varicella and can reactivate as herpes
zoster, and both diseases present a significant burden worldwide. However, the …

Varicella zoster virus–infected cerebrovascular cells produce a proinflammatory environment

D Jones, CP Neff, BE Palmer, K Stenmark… - Neurology …, 2017 - AAN Enterprises
Objective: To test whether varicella zoster virus (VZV) infection of human brain vascular cells
and of lung fibroblasts directly increases proinflammatory cytokine levels, consistent with …

[HTML][HTML] Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation

WJD Ouwendijk, HJ Van den Ham, MW Delany… - JCI insight, 2020 - ncbi.nlm.nih.gov
Primary varicella-zoster virus (VZV) infection in adults is often complicated by severe
pneumonia, which is difficult to treat and is associated with high morbidity and mortality …

Insights into the pathogenesis of varicella viruses

O Sorel, I Messaoudi - Current clinical microbiology reports, 2019 - Springer
Abstract Purpose of Review Varicella-zoster virus (VZV) is a highly contagious, neurotropic
alpha-herpes virus that causes varicella (chickenpox). VZV establishes lifelong latency in …

Humanized severe combined immunodeficient (SCID) mouse models for varicella-zoster virus pathogenesis

MG Lloyd, JF Moffat - Varicella-zoster Virus: Genetics, Pathogenesis and …, 2022 - Springer
Varicella-zoster virus (VZV) is a human-restricted virus, which raises obstacles to research.
The strict human tropism limits knowledge about its pathogenesis and creates challenges for …

Simian varicella virus causes robust transcriptional changes in T cells that support viral replication

N Arnold, I Messaoudi - Virus Research, 2017 - Elsevier
Varicella zoster virus (VZV) causes varicella (chickenpox) during acute infection. Several
studies have shown that T cells are early and preferential targets of VZV infection that play a …

Simian varicella virus: Molecular virology and mechanisms of pathogenesis

A Jankeel, I Coimbra-Ibraim, I Messaoudi - Varicella-zoster Virus: Genetics …, 2021 - Springer
Simian varicella virus (SVV) was first isolated in 1966 from African green monkeys
(Cercopithecus aethiops) imported from Nairobi, Kenya, to the Liverpool School of Tropical …