At present, it is necessary to identify specific biochemical, molecular, and genetic markers
that can reliably aid in screening digestive cancer and correlate with the degree of disease …

The incidence and mortality rates of cancer are increasing every year worldwide but the
survival rate of cancer patients is still unsatisfactory. Therefore, it is necessary to further …

Objective Emerging evidence suggests that brain angiotensin-(1–7)(Ang-(1–7)) deficiency
contributes to the pathogenesis of Alzheimer's disease (AD). Meanwhile, our previous …

Diabetic retinopathy (DR) is a complication caused by abnormal glucose metabolism, which
affects the vision and quality of life of patients and severely impacts the society at large. DR …

HACE1 is a member of the HECT domain-containing E3 ligases with 909 amino acid
residues, containing N-terminal ankyrin-repeats (ANK) and C-terminal HECT domain …

Alzheimer's Disease (AD) has currently no effective treatment; however, preventive
measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is …

Background Lung cancer, especially lung squamous cell carcinoma (LUSC), is one of the
most common malignant tumors worldwide. Currently, radiosensitization research is a vital …

As a common indication of nervous system diseases, neuroinflammation has attracted more
and more attention, especially in the process of a variety of neurodegenerative diseases …

Tripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by
the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is …

Neurodegenerative diseases (NDs) are characterized by a progressive deterioration of
neuronal function, leading to motor and cognitive damage in patients. Astrocytes are …