Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

In the absence of timely and proper treatments, injuries to articular cartilage (AC) can lead to
cartilage degeneration and ultimately result in osteoarthritis. Regenerative medicine and …

A bstract Restoration of extensive bone loss and defects remain as an unfulfilled challenge
in modern medicine. Given the critical contributions to bone homeostasis and diseases …

A leading strategy in tissue engineering is the design of biomimetic scaffolds that stimulate
the body's repair mechanisms through the recruitment of endogenous stem cells to sites of …

16.1 Background As an important component in the development of nanotechnology,
nanoparticles have been extensively explored for possible medical applications [1–4]. In …

Successful tissue regeneration strategies focus on the use of novel biomaterials, structures,
and a variety of cues to control cell behavior and promote regeneration. Studies discovered …

Stem-cell based therapy strategies are promising approaches for the treatment of bone
defects. However, extensive cell expansion steps, the low rate of cell survival and …

Tantalum (Ta) is used in orthopedic implants because it has excellent biocompatibility.
However, high elastic modulus, bio-inertness, and unsatisfactory osteointegration limits its …

The regulation of erythropoiesis in the bone marrow microenvironment is a carefully
orchestrated process that is dependent upon both systemic and local cues. Systemic …