Cancer microenvironment is created not only by malignant epithelial cells, but also by
several kinds of stromal cells. Since Paget proposed the “seed and soil” hypothesis, the …

EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Metastasis is facilitated by cancer-associated fibroblasts (CAF) in the tumor
microenvironment through mechanisms yet to be elucidated. In this study, we used a size …

Current models suggest that at a certain but yet undefined time point of tumour development
malignant cells with an aggressive phenotype start to disseminate via the blood stream into …

Lung diseases remain a significant and devastating cause of morbidity and mortality
worldwide. In contrast to many other major diseases, lung diseases notably chronic …

Simple Summary Circulating tumor cell clusters (CTC clusters) seem to play a primary role in
the metastatic spread of cancer, the main cause of death associated with this disease. The …

Vascular adventitia is thought to change functions and contribute to diseases such as
atherosclerosis, vascular restenosis, and fibrosis. To determine whether the adventitia …

Autologous lung-derived mesenchymal stem cells (LMSCs) were transplanted
endoscopically into sheep with experimental emphysema to assess their capacity to …

All cancers depend on stroma for support of growth. Leukemias, solid tumors, cancer cells
causing effusions, metastases as well as micro-disseminated cancer cells release factors …

A conference,“Stem Cells and Cell Therapies in Lung Biology and Lung Diseases,” was
held July 25 to 28, 2011 at the University of Vermont to review the current understanding of …