Abstract The Baylis-Hillman (BH) reaction plays a fascinating role in the field of synthetic and
medicinal chemistry. BH adducts and their derivatives have been used as crucial synthons …

Pyrimidine heterocycles are proven to be biologically active heterocycles, found in many
biological systems, displaying a broad spectrum of biological activities including anticancer …

This study reports two strategies for preparing O-alkyl derivatives of 6-substituted-4-
(trifluoromethyl) pyrimidin-(1 H)-ones: a linear protocol of alkylation, using a CCC-building …

A new facile synthesis of 3, 4-dihydroquinazoline-2 (1H)-thiones by an Ugi-
azide/Staudinger/aza-Wittig/cyclization sequence has been developed. The Ugi-azide …

A one-pot and diastereoselective synthesis of quinazoline-2 (1H)-thione-containing
polycyclic compounds is introduced. The reaction process includes [3+ 2] cycloaddition of …

A multicomponent reaction (MCR) strategy, alternative to the known cycloaddition reaction,
towards variously substituted 1-amino-1 H-imidazole-2 (3 H)-thione derivatives has been …

A unified approach to access Nβ-protected amino alkyl isothiocyanates using Nβ-protected
amino alkyl azides through a general strategy of Staudinger/aza-Wittig reaction is described …

Azides obtained from Baylis–Hillman adducts were treated with triphenylphosphine to give
the corresponding iminophosphoranes, which reacted with carbon disulfide at 40° C to …

A new, one-pot, regioselective preparation of 2, 5, 6, 7-tetrahydroimidazo [1, 2-a] imidazol-3-
ones by a sequential aza-Wittig/nucleophilic addition/cyclization reaction was developed …

Nitrogen heterocycles are among the most significant components of natural and
pharmaceutical products. Indeed an analysis of database of US FDA approved drugs …