Epstein–Barr virus infection

JI Cohen - New England journal of medicine, 2000 - Mass Medical Soc
The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells
cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr. 1 Four years later, in …

[HTML][HTML] EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

JB Lian, A Javed, SK Zaidi, C Lengner… - Critical Reviews™ in …, 2004 - dl.begellhouse.com
Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

The Proto-Oncogene c-myc Is a Direct Target Gene of Epstein-Barr Virus Nuclear Antigen 2

C Kaiser, G Laux, D Eick, N Jochner… - Journal of …, 1999 - Am Soc Microbiol
Epstein-Barr virus (EBV) infects and transforms primary B lymphocytes in vitro. Viral infection
initiates the cell cycle entry of the resting B lymphocytes. The maintenance of proliferation in …

Ets target genes: past, present and future

VI Sementchenko, DK Watson - Oncogene, 2000 - nature.com
Ets is a family of transcription factors present in species ranging from sponges to human. All
family members contain an approximately 85 amino acid DNA binding domain, designated …

Cancers associated with human gammaherpesviruses

KW Wen, L Wang, JR Menke, B Damania - The FEBS journal, 2022 - Wiley Online Library
Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

B Zhao, J Zou, H Wang, E Johannsen… - Proceedings of the …, 2011 - National Acad Sciences
Epstein-Barr virus nuclear antigen 2 (EBNA2) regulation of transcription through the cell
transcription factor RBPJ is essential for resting B-lymphocyte (RBL) conversion to immortal …

The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE

X Tong, R Drapkin, R Yalamanchili… - … and cellular biology, 1995 - Am Soc Microbiol
Epstein-Barr virus nuclear antigen 2 (EBNA 2) activates transcription of specific genes and is
essential for B-lymphocyte transformation. EBNA 2 has an acidic activation domain which …

NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells

ED Cahir-McFarland, DM Davidson… - Proceedings of the …, 2000 - National Acad Sciences
Epstein–Barr virus (EBV) transforms B lymphocytes into lymphoblastoid cell lines usurping
the Notch and tumor necrosis factor receptor pathways to effect transcription including NF-κB …

Epstein–Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter

L Wang, SR Grossman, E Kieff - Proceedings of the …, 2000 - National Acad Sciences
The Epstein–Barr virus (EBV) nuclear protein 2 (EBNA2) and herpes simplex virion protein
16 (VP16) acidic domains that mediate transcriptional activation now are found to have …