Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Copper, an essential micronutrient, controls multiple fundamental processes throughout all
forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High …

Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …

Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Copper is an essential element for most aerobic organisms, with an important function as a
structural and catalytic cofactor, and in consequence, it is implicated in several biological …

Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family,
which has been initially discovered as the enzyme responsible for insulin catabolism; …

Background Copper was reported to be involved in the onset and progression of cancer.
Proteins in charge of copper uptake and distribution, as well as cuproenzymes, are altered …

The ubiquitin-proteasome system and the autophagy-lysosome system are two major
intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms …