The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …

The selective functionalization of strong, typically inert carbon-hydrogen (C–H) bonds in
organic molecules is changing synthetic chemistry. However, the undirected …

Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to
alleviate pain and inflammation, regulate motility and appetite, and produce anticancer …

A new method for the stereoselective synthesis of highly functionalized oxygen heterocycles
using allyl or benzyl alcohols as alkylating agents is presented. The process is efficient and …

Abstract β-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block
for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well …

Palmitoylethanolamide is a bioactive lipid that strongly alleviates pain and inflammation in
animal models and in humans. Its signaling activity is terminated through degradation by N …

Highlights•NAAA is a key enzyme controlling the levels of bioactive N-acylethanolamines.•
Novel, systemically active inhibitors are now available to study NAAA roles in vivo.•NAAA …

The β-lactam ring represents a valuable moiety that can induce covalent binding of an
inhibitor to its target. In this study, we explored di-and tripeptides with β-lactam electrophilic …

Roselle (Hibiscus sabdariffa L.) is a comestible plant known for its fleshy red calyces that are
used in making a wide range of foods such as wine, juice, jam, syrup, pudding, cakes, ice …