Injured peripheral nerves but not central nerves have the capacity to regenerate and
reinnervate their target organs. After the two most severe peripheral nerve injuries of six …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Nerve injury triggers the conversion of myelin and non‐myelin (Remak) Schwann cells to a
cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

Injured peripheral nerves regenerate their lost axons but functional recovery in humans is
frequently disappointing. This is so particularly when injuries require regeneration over long …

Peripheral nerve injuries are common and frequently result in incomplete functional
recovery even with optimal surgical treatment. Permanent motor and sensory deficits are …

Enhancing the regeneration of axons is often considered to be a therapeutic target for
improving functional recovery after peripheral nerve injury. In this review, the evidence for …

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for
regeneration. Normally providing strong regenerative support, these cells fail in aging …