The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …

The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue
homeostasis, and their dysregulation contributes to human cancer. Here, we discover …

Many potential targets for CAR-T cells in solid tumors are expressed in some normal tissues,
raising concern for off-tumor toxicity. Following lymphodepletion, CAR-T cells targeting the …

Abstract 30 years after the identification of WNTs, their signal transduction has become
increasingly complex, with the discovery of more than 15 receptors and co-receptors in …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a
known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …