Incidence and mortality of colorectal cancer (CRC) are increasing worldwide, suggesting
broad changes in the epidemiology of CRC. In this Review, we discuss the changes that are …

The treatment of women's health-related conditions, including reproductive tract and
pregnancy disorders, faces distinct challenges and microenvironments, such as the vaginal …

Background & Aims Patients with early-onset colorectal cancer (eoCRC) are managed
according to guidelines that are not age-specific. A multidisciplinary international group …

Colorectal cancer (CRC) epidemiology is changing due to a birth cohort effect, first
recognized by increasing incidence of early onset CRC (EOCRC, age< 50 years). In this …

Background Preterm birth is the leading cause of childhood mortality and morbidity. We
aimed to provide a comprehensive systematic review on randomized controlled trials (RCTs) …

OBJECTIVE Randomized trials have found benefits of both vaginal progesterone and 17-
alpha-hydroxyprogesterone caproate in the prevention of recurrent preterm birth. A previous …

Background Incidence rates of colorectal cancer (CRC) are increasing among younger
adults and in mid-life, implicating exposures in early life as risk factors. We examined the …

Hydroxyprogesterone caproate (Makena) is an injectable drug for the prevention of preterm
birth, ie, birth prior to 37 weeks of gestation. About 1 in 10 US infants is born preterm, 1 a …

Spontaneous preterm birth is multifactorial, and underlying etiologies remain incompletely
understood. Supplementation with progestogens, including 17-alpha hydroxyprogesterone …

Background Incidence rates of colorectal cancer (CRC) are increasing among adults born in
and after the 1960s, implicating pregnancy-related exposures introduced at that time as risk …