Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

RING E3s comprise the largest family of ubiquitin (UB) and ubiquitin-like protein (UBL)
ligases. RING E3s typically promote UB or UBL transfer from the active site of an associated …

▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

Cullin–RING complexes comprise the largest known class of ubiquitin ligases. Owing to the
great diversity of their substrate-receptor subunits, it is possible that there are hundreds of …

Ubiquitylation? the conjugation of proteins with a small protein called ubiquitin? touches
upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases …

Cullin-RING ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central
cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent …

Nrf2 is a transcription factor that has emerged as the cell's main defense mechanism against
many harmful environmental toxicants and carcinogens. Nrf2 is negatively regulated by …

Xie and colleagues previously isolated the Arabidopsis COI1 gene that is required for
response to jasmonates (JAs), which regulate root growth, pollen fertility, wound healing …

Abstract In Arabidopsis (Arabidopsis thaliana), the carotenoid cleavage dioxygenases
MORE AXILLARY GROWTH3 (MAX3) and MAX4 act together with MAX1 to produce a …

SCF ubiquitin ligases control various processes by marking regulatory proteins for ubiquitin-
dependent proteolysis. To illuminate how SCF complexes are regulated, we sought proteins …