X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular
structural biology due to the unique combination of spatial coherence, extreme peak …

The high peak brilliance and femtosecond pulse duration of X-ray free-electron lasers
(XFELs) provide new scientific opportunities for experiments in physics, chemistry and …

X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying
macromolecules at biologically relevant temperatures. Moreover, when combined with …

Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi,
and bacteria. Light is detected by a bilin cofactor, but it remains elusive how this leads to …

Phytochromes are ubiquitous photosensor proteins, which control the growth, reproduction
and movement in plants, fungi and bacteria. Phytochromes switch between two …

The advent of the X-ray free electron laser (XFEL) in the last decade created the discipline of
serial crystallography but also the challenge of how crystal samples are delivered to X-ray …

A sample-injection device has been developed at SPring-8 Angstrom Compact Free-
Electron Laser (SACLA) for serial femtosecond crystallography (SFX) at atmospheric …

Serial femtosecond crystallography (SFX) allows structures of proteins to be determined at
room temperature with minimal radiation damage. A highly viscous matrix acts as a crystal …

After decades of diligent development at synchrotron light sources, the field of time-resolved
crystallography (TRX) is elevating to new heights. Driven by the appearance of X-ray free …

The focus of structural biology is shifting from the determination of static structures to the
investigation of dynamical aspects of macromolecular function. With time-resolved …