Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2)
prevents the induction of apoptosis not only in malignant cells, but also in normal cellular …

Signal transducer and activator of transcription (STAT) proteins are a 7-member family of
cytoplasmic transcription factors that contribute to signal transduction by cytokines …

Myeloid neoplasms with erythroid or megakaryocytic differentiation include pure erythroid
leukemia, myelodysplastic syndrome with erythroid features, and acute megakaryoblastic …

The past few years have seen remarkable progress in our understanding of embryonic stem
cell (ES cell) biology. The necessity of examining human ES cells in culture, coupled with …

The aggressiveness of a tumor is partly attributed to its resistance to chemotherapeutic
agent-induced apoptosis. Cysteine-rich 61 (Cyr61), from the CCN gene family, is a secreted …

The role of apoptotic pathways in the development and function of the megakaryocyte
lineage has generated renewed interest in recent years. This has been driven by the advent …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

The process of megakaryopoiesis and platelet production is complex, with the potential for
regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Our laboratories have previously identified the α7 nAChR–JAK2 pathway as playing a
central role in nicotine-induced neuroprotection. We have also reported that the angiotensin …