It is well known that radiation therapy causes lymphopenia in patients and that this is
correlated with a negative outcome. The mechanism is not well understood because …

Purpose Emerging evidence suggests a detrimental prognostic association between
radiation-induced lymphopenia (RIL) and pathologic response, progression-free survival …

Simple Summary Emerging evidence indicates that the immune system plays an important
role in controlling tumors during radiotherapy, and radiation-induced immune toxicity such …

Background Radiation-related lymphopenia has been associated with suboptimal tumor
control rates leading to inferior survival outcomes. To date, no standardized dose constraints …

Abstract FLASH radiotherapy (FLASH-RT) delivers radiation treatment at an ultra-high dose
rate that is several orders of magnitude higher than current clinical practice. In multiple …

Metastasis to lymph nodes (LNs) is a common feature of disease progression in most solid
organ malignancies. Consequently, LN biopsy and lymphadenectomy are common clinical …

Simple Summary Radiotherapy is as an important part of esophageal cancer (EC) treatment.
However, it often causes severe radiation-induced lymphopenia (RIL). The aim of the current …

Background Lymphopenia is a known significant factor for treatment outcome in cancer
patients, with underlying risk factor poorly understood in breast cancer. We hypothesize that …

We have developed a time-dependent computational framework, hematological dose
(HEDOS), to estimate dose to circulating blood cells from radiation therapy treatment fields …

Introduction Hematologic toxicity (HT), particularly leukopenia, is a common side-effect of
oncologic treatments for pelvic malignancies. Pelvic nodal radiotherapy (PNRT) has been …