Emerging technologies for improved deep brain stimulation

H Cagnan, T Denison, C McIntyre, P Brown - Nature biotechnology, 2019 - nature.com
Deep brain stimulation (DBS) is an effective treatment for common movement disorders and
has been used to modulate neural activity through delivery of electrical stimulation to key …

Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy

P Krack, J Volkmann, G Tinkhauser… - Movement …, 2019 - Wiley Online Library
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease

TA Dembek, J Roediger, A Horn, P Reker… - Annals of …, 2019 - Wiley Online Library
Objective To investigate whether functional sweet spots of deep brain stimulation (DBS) in
the subthalamic nucleus (STN) can predict motor improvement in Parkinson disease (PD) …

Deep brain stimulation programming for movement disorders: current concepts and evidence-based strategies

T Koeglsperger, C Palleis, F Hell, JH Mehrkens… - Frontiers in …, 2019 - frontiersin.org
Deep brain stimulation (DBS) has become the treatment of choice for advanced stages of
Parkinson's disease, medically intractable essential tremor, and complicated segmental and …

EuroInf 2: subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease

HS Dafsari, P Martinez‐Martin, A Rizos… - Movement …, 2019 - Wiley Online Library
Objective Real‐life observational report of clinical efficacy of bilateral subthalamic
stimulation (STN‐DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on …

[HTML][HTML] Update on current technologies for deep brain stimulation in Parkinson's disease

M Paff, A Loh, C Sarica, AM Lozano… - Journal of movement …, 2020 - ncbi.nlm.nih.gov
Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients
with Parkinson's disease and other movement disorders. Recent developments in DBS lead …

[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

Automated deep brain stimulation programming based on electrode location: a randomised, crossover trial using a data-driven algorithm

J Roediger, TA Dembek, J Achtzehn… - The Lancet Digital …, 2023 - thelancet.com
Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is highly
effective in controlling motor symptoms in patients with Parkinson's disease. However …

[HTML][HTML] Directional deep brain stimulation for Parkinson's disease: results of an international crossover study with randomized, double-blind primary endpoint

A Schnitzler, P Mir, MA Brodsky, L Verhagen… - … : Technology at the …, 2022 - Elsevier
Objective Published reports on directional deep brain stimulation (DBS) have been limited to
small, single-center investigations. Therapeutic window (TW) is used to describe the range …

Closing the loop in psychiatric deep brain stimulation: physiology, psychometrics, and plasticity

AS Widge - Neuropsychopharmacology, 2024 - nature.com
Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …