Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

The implications of neurogenic inflammation and neuroinflammation in the pathophysiology
of migraine have been clearly demonstrated in preclinical migraine models involving several …

Migraine is the second most common form of headache disorder and the second leading
cause of disability worldwide. Cognitive symptoms ranked second resulting in migraine …

The role of neuroinflammation in the pathophysiology of migraines is increasingly being
recognized, and cytokines, which are important endogenous substances involved in …

The communication between calcitonin gene-related peptide (CGRP) and cytokines plays a
prominent role in maintaining trigeminal ganglion (TG) and trigeminovascular sensitization …

Background The initiation of migraine headaches and the involvement of neuroinflammatory
signaling between parenchymal and meningeal cells remain unclear. Experimental …

Epilepsy is one of the most common chronic diseases of the central nervous system (CNS).
Treatment of epilepsy remains, however, a clinical challenge with over 30% of patients not …

The elaborate mechanisms of depression have always been a research hotspot in recent
years, and the pace of research has never ceased. The P2X7 receptor (P2X7R) belongs to …

Introduction This overview of systematic reviews (SRs) systematically collected, evaluated,
and combined the evidence for migraine treatment with transcranial magnetic stimulation …

Neurodegenerative diseases seriously affect patients' physical and mental health, reduce
their quality of life, and impose a heavy burden on society. However, their treatment remains …