Endometriosis: Recent advances that could accelerate diagnosis and improve care

MJ Griffiths, AW Horne, DA Gibson, N Roberts… - Trends in Molecular …, 2024 - cell.com
Endometriosis is a common disorder associated with pain, gastrointestinal and urinary
symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions …

[HTML][HTML] Pathogenesis of Endometriosis and Endometriosis-Associated Cancers

A Adilbayeva, J Kunz - International journal of molecular sciences, 2024 - mdpi.com
Endometriosis is a hormone-dependent, chronic inflammatory condition that affects 5–10%
of reproductive-aged women. It is a complex disorder characterized by the growth of …

The Known, the Unknown and the Future of the Pathophysiology of Endometriosis

MA Ochoa Bernal, AT Fazleabas - International Journal of Molecular …, 2024 - mdpi.com
Endometriosis is one of the most common causes of chronic pelvic pain and infertility,
affecting 10% of women of reproductive age. A delay of up to 9 years is estimated between …

Long-Term Maintenance of Viable Human Endometrial Epithelial Cells to Analyze Estrogen and Progestin Effects

MA Riaz, FL Kary, A Jensen, F Zeppernick… - Cells, 2024 - mdpi.com
There are fewer investigations conducted on human primary endometrial epithelial cells
(HPEECs) compared to human primary endometrial stromal cells (HPESCs). One of the …

[HTML][HTML] Single-cell transcriptomic analysis of immune cell dynamics in the healthy human endometrium

K Chen, Q Yu, Q Sha, J Wang, J Fang, X Li… - … and Biophysics Reports, 2024 - Elsevier
The microenvironment of the endometrial immune system is crucial to the success of
placental implantation and healthy pregnancy. However, the functionalities of immune cells …

Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions

GW Burns, Z Fu, EL Vegter, ZB Madaj, E Greaves… - bioRxiv, 2024 - biorxiv.org
The mechanisms underlying the pathophysiology of endometriosis, characterized by the
presence of endometrium-like tissue outside the uterus, remain poorly understood. This …

Tracing Endometriosis: Coupling deeply phenotyped, single-cell based Endometrial Differences and AI for disease pathology and prediction

L Duempelmann, S Sheppard, A Duo, J Skrabalova… - bioRxiv, 2024 - biorxiv.org
Endometriosis, affecting 1 in 9 women, presents treatment and diagnostic challenges. To
address these issues, we generated the biggest single-cell atlas of endometrial tissue to …

Single-Cell and Spatial Transcriptomic Profiling Revealed Niche Interactions Sustaining Growth of Endometriotic Lesions

S Liu, X Li, Z Gu, J Wu, S Jia, J Shi, Y Dai, Y Wu… - Available at SSRN … - papers.ssrn.com
Endometriosis is a chronic condition with limited therapeutic options. The molecular
aberrations promoting ectopic attachment and interactions with the local microenvironment …