Nuclear cloning and epigenetic reprogramming of the genome

WM Rideout III, K Eggan, R Jaenisch - Science, 2001 - science.org
Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at
most a few percent of manipulated embryos resulting in live births. Many of those that …

The current status and future of commercial embryo transfer in cattle

JF Hasler - Animal reproduction science, 2003 - Elsevier
A commercially viable cattle embryo transfer (ET) industry was established in North America
during the early 1970s, approximately 80 years after the first successful embryo transfer was …

Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses

JR Hill, RC Burghardt, K Jones, CR Long… - Biology of …, 2000 - academic.oup.com
The production of cloned animals is, at present, an inefficient process. This study focused on
the fetal losses that occur between Days 30–90 of gestation. Fetal and placental …

The health profile of cloned animals

JB Cibelli, KH Campbell, GE Seidel, MD West… - Nature …, 2002 - nature.com
14 develop abnormally is currently unjustified on scientific grounds and should not be used
by policymakers or other groups as an argument to ban all human cloning research. In our …

[PDF][PDF] Assisted reproductive technologies in cattle: a review

RJ Mapletoft, JF Hasler - Revue Scientifique et Technique-Office …, 2005 - researchgate.net
Over a period of approximately thirty years, commercial bovine embryo transfer has become
a large international business. The technology is well established, and more than 500,000 …

Buffalos (Bubalus bubalis) cloned by nuclear transfer of somatic cells

D Shi, F Lu, Y Wei, K Cui, S Yang, J Wei… - Biology of …, 2007 - academic.oup.com
Cloning of buffalos (Bubalus bubalis) through nuclear transfer is a potential alternative
approach in genetic improvement of buffalos. However, to our knowledge, cloned offspring …

[HTML][HTML] Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

X Liu, Y Wang, W Guo, B Chang, J Liu, Z Guo… - Nature …, 2013 - nature.com
Zinc-finger nickases (ZFNickases) are a type of programmable nuclease that can be
engineered from zinc-finger nucleases to induce site-specific single-strand breaks or nicks …

Production of the first cloned camel by somatic cell nuclear transfer

NA Wani, U Wernery, FAH Hassan… - Biology of …, 2010 - academic.oup.com
In this study, we demonstrate the use of somatic cell nuclear transfer to produce the first
cloned camelid, a dromedary camel (Camelus dromedarius) belonging to the family …

[PDF][PDF] Influence of bovine sperm DNA fragmentation and oxidative stress on early embryo in vitro development outcome

R Simoes, WB Feitosa, AFP Siqueira, M Nichi… - …, 2013 - rep.bioscientifica.com
In ruminants, the greatest period of embryonic loss coincides with the period of elongation
when the embryonic disc is formed and gastrulation occurs prior to implantation. The impact …

[HTML][HTML] Limited demethylation leaves mosaic‐type methylation states in cloned bovine pre‐implantation embryos

YK Kang, JS Park, DB Koo, YH Choi, SU Kim… - The EMBO …, 2002 - embopress.org
Cloning by nuclear transfer (NT) has been riddled with difficulties: most clones die before
birth and survivors frequently display growth abnormalities. The cross‐species similarity in …