The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Antibody-induced procoagulant platelets in severe COVID-19 infection

K Althaus, I Marini, J Zlamal, L Pelzl… - Blood, The Journal …, 2021 - ashpublications.org
The pathophysiology of COVID-19–associated thrombosis seems to be multifactorial. We
hypothesized that COVID-19 is accompanied by procoagulant platelets with subsequent …

Platelet and megakaryocyte roles in innate and adaptive immunity

M Koupenova, AC Livada, CN Morrell - Circulation research, 2022 - Am Heart Assoc
Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

COVID-19 induces a hyperactive phenotype in circulating platelets

SP Comer, S Cullivan, PB Szklanna, L Weiss… - PLoS …, 2021 - journals.plos.org
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2), has affected over 30 million globally to date …

Emerging roles for platelets as immune and inflammatory cells

CN Morrell, AA Aggrey, LM Chapman… - Blood, The Journal of …, 2014 - ashpublications.org
Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …

The role of platelets in mediating a response to human influenza infection

M Koupenova, HA Corkrey, O Vitseva, G Manni… - Nature …, 2019 - nature.com
Influenza infection increases the incidence of myocardial infarction but the reason is
unknown. Platelets mediate vascular occlusion through thrombotic functions but are also …

Platelets and infection–an emerging role of platelets in viral infection

A Assinger - Frontiers in immunology, 2014 - frontiersin.org
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …

Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2

PS Sung, TF Huang, SL Hsieh - Nature communications, 2019 - nature.com
Platelet-leukocyte interactions amplify inflammatory reactions, but the underlying
mechanism is still unclear. CLEC5A and CLEC2 are spleen tyrosine kinase (Syk)-coupled C …

Platelets and SARS-CoV-2 during COVID-19: immunity, thrombosis, and beyond

A Sciaudone, H Corkrey, F Humphries… - Circulation …, 2023 - Am Heart Assoc
COVID-19 is characterized by dysregulated thrombosis and coagulation that can increase
mortality in patients. Platelets are fast responders to pathogen presence, alerting the …