Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Cholesterol homeostasis is critical and necessary for the body's functions.
Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular …

Cardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast
growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a …

Abstract The impacts of Deepwater Horizon (DWH) oil on morphology and function during
embryonic development have been documented for a number of fish species, including the …

Cholesterol metabolism is a well-defined responder to dietary intakes and a classic
biomarker of cardiovascular health. For this reason, circulating cholesterol levels have …

The cholesterol biosynthesis pathway, also referred to as the mevalonate (MVA) pathway, is
responsible for the biosynthesis of two key isoprenoids: farnesyl pyrophosphate (FPP) and …

Familial hypercholesterolemia (FH) is an autosomal dominant disease mainly caused by
mutations in the low-density lipoprotein receptor (LDLR) gene. FH patients present a wide …

Dichlorvos is a common crop insecticide widely used by people which causes extensive and
serious environmental pollution. However, it has been shown that organophosphorus …

Although many genome-wide association studies (GWASs) have evaluated the association
with metabolic disorders, the current study is the first attempt to analyze the genetic risk …

Представлены современные данные о генетических и эпигенетических факторах
риска возникновения и развития патологий сердечно-сосудистой системы. Приведены …