IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations
In response to the need to minimize the use of experimental animals, new approach
methodologies (NAMs) using advanced technology have emerged in the 21st century …
methodologies (NAMs) using advanced technology have emerged in the 21st century …
Machine learning-based hazard-driven prioritization of features in nontarget screening of environmental high-resolution mass spectrometry data
K Arturi, J Hollender - Environmental Science & Technology, 2023 - ACS Publications
Nontarget high-resolution mass spectrometry screening (NTS HRMS/MS) can detect
thousands of organic substances in environmental samples. However, new strategies are …
thousands of organic substances in environmental samples. However, new strategies are …
TOXRIC: a comprehensive database of toxicological data and benchmarks
L Wu, B Yan, J Han, R Li, J Xiao, S He… - Nucleic Acids …, 2023 - academic.oup.com
The toxic effects of compounds on environment, humans, and other organisms have been a
major focus of many research areas, including drug discovery and ecological research …
major focus of many research areas, including drug discovery and ecological research …
[HTML][HTML] Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke
Introduction Wildfires are a threat to public health world-wide that are growing in intensity
and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain …
and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain …
Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved …
Per-and polyfluoroalkyl substances (PFAS) have emerged as high-priority contaminants due
to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across …
to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across …
Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory …
LE Koval, KL Dionisio, KP Friedman… - Journal of exposure …, 2022 - nature.com
Background Although evidence linking environmental chemicals to breast cancer is
growing, mixtures-based exposure evaluations are lacking. Objective This study aimed to …
growing, mixtures-based exposure evaluations are lacking. Objective This study aimed to …
[HTML][HTML] Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia
A Chao, J Grossman, C Carberry, Y Lai… - Environment …, 2022 - Elsevier
Background Environmental health research has recently undergone a dramatic shift, with
ongoing technological advancements allowing for broader coverage of exposure and …
ongoing technological advancements allowing for broader coverage of exposure and …
Wildfire variable toxicity: Identifying biomass smoke exposure groupings through transcriptomic similarity scoring
The prevalence of wildfires continues to grow globally with exposures resulting in increased
disease risk. Characterizing these health risks remains difficult due to the wide landscape of …
disease risk. Characterizing these health risks remains difficult due to the wide landscape of …
Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research
Extracellular vesicles (EVs) represent small, membrane-enclosed particles that are derived
from parent cells and are secreted into the extracellular space. Once secreted, EVs can then …
from parent cells and are secreted into the extracellular space. Once secreted, EVs can then …