IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making

X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations

J Jeong, D Kim, J Choi - Toxicology in Vitro, 2022 - Elsevier
In response to the need to minimize the use of experimental animals, new approach
methodologies (NAMs) using advanced technology have emerged in the 21st century …

Machine learning-based hazard-driven prioritization of features in nontarget screening of environmental high-resolution mass spectrometry data

K Arturi, J Hollender - Environmental Science & Technology, 2023 - ACS Publications
Nontarget high-resolution mass spectrometry screening (NTS HRMS/MS) can detect
thousands of organic substances in environmental samples. However, new strategies are …

TOXRIC: a comprehensive database of toxicological data and benchmarks

L Wu, B Yan, J Han, R Li, J Xiao, S He… - Nucleic Acids …, 2023 - academic.oup.com
The toxic effects of compounds on environment, humans, and other organisms have been a
major focus of many research areas, including drug discovery and ecological research …

[HTML][HTML] Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke

CK Carberry, LE Koval, A Payton, H Hartwell… - Environment …, 2022 - Elsevier
Introduction Wildfires are a threat to public health world-wide that are growing in intensity
and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain …

Extracellular vesicles altered by a per- and polyfluoroalkyl substance mixture: in vitro dose-dependent release, chemical content, and microRNA signatures involved …

CK Carberry, J Bangma, L Koval… - Toxicological …, 2024 - academic.oup.com
Per-and polyfluoroalkyl substances (PFAS) have emerged as high-priority contaminants due
to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across …

Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory …

LE Koval, KL Dionisio, KP Friedman… - Journal of exposure …, 2022 - nature.com
Background Although evidence linking environmental chemicals to breast cancer is
growing, mixtures-based exposure evaluations are lacking. Objective This study aimed to …

[HTML][HTML] Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia

A Chao, J Grossman, C Carberry, Y Lai… - Environment …, 2022 - Elsevier
Background Environmental health research has recently undergone a dramatic shift, with
ongoing technological advancements allowing for broader coverage of exposure and …

Wildfire variable toxicity: Identifying biomass smoke exposure groupings through transcriptomic similarity scoring

LE Koval, CK Carberry, YH Kim… - … science & technology, 2022 - ACS Publications
The prevalence of wildfires continues to grow globally with exposures resulting in increased
disease risk. Characterizing these health risks remains difficult due to the wide landscape of …

Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research

CK Carberry, D Keshava, A Payton, GJ Smith… - Journal of exposure …, 2022 - nature.com
Extracellular vesicles (EVs) represent small, membrane-enclosed particles that are derived
from parent cells and are secreted into the extracellular space. Once secreted, EVs can then …