Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …

A novel coronavirus strain (COVID-19) caused severe illness and mortality worldwide from
31 December 2019 to 21 March 2023. As of this writing, 761,071,826 million cases have …

Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …

This paper explores a dual inhibition of main protease (Mpro) and nonstructural protein
10/nonstructural protein 16 (NSP16) methyltransferase complex as the key targets for …

Medicinal herbs have long been utilized to treat various diseases or to relieve the symptoms
of some ailments for extended periods. The present investigation demonstrates the …

Over the last century, outbreaks and pandemics have occurred with disturbing regularity,
necessitating advance preparation and large-scale, coordinated response. Here, we …

The pandemic caused by SARS-CoV-2 coronavirus infection starting from December 2019
raised global health concern. The negative effects of conventional medications, and the rise …

SARS‐CoV‐2 infection causes disruptions in inflammatory pathways, which fundamentally
contribute to COVID‐19 pathophysiology. The present review critically evaluates the gaps in …

This study explores the capability of thiazoles as potent inhibitors of SARS‐CoV‐2 Mpro.
Seventeen thiazoles (1–17) were screened for their linking affinity with the active site of …

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global health concern. Three years …