Homocysteine and cardiovascular disease
An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …
5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review
LD Botto, Q Yang - American journal of epidemiology, 2000 - academic.oup.com
Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis
DS Wald, M Law, JK Morris - Bmj, 2002 - bmj.com
Objective: To assess whether the association of serum homocysteine concentration with
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is …
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is …
MTHFR 677C→ T polymorphism and risk of coronary heart disease: a meta-analysis
M Klerk, P Verhoef, R Clarke, HJ Blom, FJ Kok… - Jama, 2002 - jamanetwork.com
ContextIn observational studies, individuals with elevated levels of plasma homocysteine
tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR …
tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR …
Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis
L Brattström, DEL Wilcken, J Öhrvik, L Brudin - Circulation, 1998 - Am Heart Assoc
Background—The results of retrospective and prospective case-control studies have clearly
established that mild elevations of the plasma homocysteine level are associated with …
established that mild elevations of the plasma homocysteine level are associated with …
Hyperhomocysteinemia, atherosclerosis and thrombosis
M Cattaneo - Thrombosis and haemostasis, 1999 - thieme-connect.com
High plasma levels of homocysteine are the results of the interplay between congenital and
environmental factors. In the last two decades, a growing amount of interest has focused on …
environmental factors. In the last two decades, a growing amount of interest has focused on …
[HTML][HTML] The controversy over homocysteine and cardiovascular risk
PM Ueland, H Refsum, SAA Beresford… - The American journal of …, 2000 - Elsevier
Elevated plasma total homocysteine (tHcy) is a risk factor for occlusive cardiovascular
disease (CVD). This concept is based on the observations of premature vascular disease in …
disease (CVD). This concept is based on the observations of premature vascular disease in …
Homocysteine and diabetes: Role in macrovascular and microvascular complications
E Muzurović, I Kraljević, M Solak, S Dragnić… - Journal of Diabetes and …, 2021 - Elsevier
Diabetes mellitus (DM) can lead to the development of macro-and microvascular
complications. Homocysteine (Hcy) may play a role in the development of cardiovascular …
complications. Homocysteine (Hcy) may play a role in the development of cardiovascular …
5, 10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview
Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in
genes regulating blood cell development or homeostasis. Folate deficiency has been …
genes regulating blood cell development or homeostasis. Folate deficiency has been …
Folates and cardiovascular disease
MC Verhaar, E Stroes, TJ Rabelink - … , thrombosis, and vascular …, 2002 - Am Heart Assoc
It is increasingly recognized that folates may play a role in the prevention of cardiovascular
disease. Over the last few years, several studies have reported beneficial effects of folates …
disease. Over the last few years, several studies have reported beneficial effects of folates …