An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …

Objective: To assess whether the association of serum homocysteine concentration with
ischaemic heart disease, deep vein thrombosis and pulmonary embolism, and stroke is …

ContextIn observational studies, individuals with elevated levels of plasma homocysteine
tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR …

Background—The results of retrospective and prospective case-control studies have clearly
established that mild elevations of the plasma homocysteine level are associated with …

High plasma levels of homocysteine are the results of the interplay between congenital and
environmental factors. In the last two decades, a growing amount of interest has focused on …

Elevated plasma total homocysteine (tHcy) is a risk factor for occlusive cardiovascular
disease (CVD). This concept is based on the observations of premature vascular disease in …

Diabetes mellitus (DM) can lead to the development of macro-and microvascular
complications. Homocysteine (Hcy) may play a role in the development of cardiovascular …

Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in
genes regulating blood cell development or homeostasis. Folate deficiency has been …

It is increasingly recognized that folates may play a role in the prevention of cardiovascular
disease. Over the last few years, several studies have reported beneficial effects of folates …