Hypoxia has been shown to have a role in the pathogenesis of several forms of liver
disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved …

Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a
vast variety of proteins in order to modulate their function. Sumoylation has emerged as an …

Cbx4 is a polycomb group protein that is also a SUMO E3 ligase, but its potential roles in
tumorigenesis remain to be explored. Here, we report that Cbx4, but not other members of …

Background Spindle and kinetochore-associated complex subunit 3 (SKA3) plays an
important role in cell proliferation by regulating the separation of chromosomes and their …

Background The adaptation to hypoxia is mainly controlled by the HIF transcription factors.
Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients …

Acute kidney injury (AKI) due to ischemia is an important contributor to the progression of
chronic kidney disease (CKD). Key mediators of cellular adaptation to hypoxia are oxygen …

Objective To determine whether obstructive sleep apnea (OSA) and/or nocturnal hypoxemia
are associated with the severity of liver injury in patients with pediatric nonalcoholic fatty liver …

Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are
common conditions, frequently encountered in patients with metabolic disorders. OSAS has …

SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic
patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic …

The putative neuroprotective properties of various flavonoids have long been reported.
Among this class of chemicals, quercetin, a major flavone/flavonol naturally occurring in …