Structured edible lipid-based particle systems for oral drug-delivery
Oral administration is the most popular and patient-compliant route for drug delivery, though
it raises great challenges due to the involvement of the gastro-intestine (GI) system and the …
it raises great challenges due to the involvement of the gastro-intestine (GI) system and the …
An emerging era in manufacturing of drug delivery systems: Nanofabrication techniques
Nanotechnology has the capability of making significant contributions to healthcare.
Nanofabrication of multifunctional nano-or micro-character systems is becoming incredibly …
Nanofabrication of multifunctional nano-or micro-character systems is becoming incredibly …
Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded mucoadhesive buccal tablets for efficient delivery of Lornoxicam in …
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively
to manage pain and inflammatory conditions. However, the drug possesses poor aqueous …
to manage pain and inflammatory conditions. However, the drug possesses poor aqueous …
Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer's disease: A preclinical evidence
Ferulic acid (FA) is a ubiquitous natural plant bioactive with distinctive promise in
neurodegenerative disorders. However, its therapeutic efficacy gets compromised owing to …
neurodegenerative disorders. However, its therapeutic efficacy gets compromised owing to …
Intranasal delivery of darunavir-loaded mucoadhesive in situ gel: Experimental design, in vitro evaluation, and pharmacokinetic studies
The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low
perfusion of the drug to the brain. The objective of the current investigation was to design …
perfusion of the drug to the brain. The objective of the current investigation was to design …
Formulation, optimization, and characterization of rifampicin-loaded solid lipid nanoparticles for the treatment of tuberculosis
NV Chokshi, HN Khatri, MM Patel - Drug development and …, 2018 - Taylor & Francis
Mycobacterium tuberculosis, being the causative infectious agent, is the leading cause of
death worldwide amongst the infectious disease. The low bioavailability of rifampicin (RIF) …
death worldwide amongst the infectious disease. The low bioavailability of rifampicin (RIF) …
Importance of P-gp inhibitors and nanoengineered approaches for effective delivery of anti-retroviral drugs across barriers in HIV management
HIV infection has been a major global public health issue that hinders the body's ability to
fight against the disease. For their treatment, antiretroviral therapy (ART) has been used to …
fight against the disease. For their treatment, antiretroviral therapy (ART) has been used to …
Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis
The targeting and mucoadhesive features of chitosan (CS)-linked solid lipid nanoparticles
(SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a …
(SLNs) were exploited to efficiently deliver fexofenadine (FEX) into the colon, forming a …
Investigating the impact of delivery system design on the efficacy of self-amplifying RNA vaccines
G Anderluzzi, G Lou, S Gallorini, M Brazzoli, R Johnson… - Vaccines, 2020 - mdpi.com
messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-
attenuated and subunit vaccines. In order for these to be applied for clinical use, they require …
attenuated and subunit vaccines. In order for these to be applied for clinical use, they require …
Pazopanib-laden lipid based nanovesicular delivery with augmented oral bioavailability and therapeutic efficacy against non-small cell lung cancer
The present investigation deals with the pazopanib-loaded solid lipid nanoparticles (Pazo-
SLNs) and their in-vitro and in-vivo assessments. Quality by design approach employing the …
SLNs) and their in-vitro and in-vivo assessments. Quality by design approach employing the …