Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound
influence on the development and progression of human cancers. Compared with normal …

Cysteinyl leukotrienes (CysLTs) are a family of inflammatory lipid mediators synthesized
from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and …

Leukotrienes have been implicated in the regulation of immune responses, including
inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic …

Leukotrienes (LT), both the cysteinyl LTs, LTC4, LTD4 and LTE4, as well as LTB4 have been
implicated in the clinical course, physiologic changes, and pathogenesis of asthma. The …

Hematopoietic stem cell (HSC) transplantation is a potentially curative treatment for
numerous hematological malignancies. The transplant procedure as performed today takes …

Arachidonate metabolism by 5-lipoxygenase (5-LO) coincides with the translocation of the
enzyme from a soluble to a pelletable fraction in thoroughly disrupted granulocytic cells …

The concept of the haematopoietic stem cell (HSC) niche was formulated by Schofield in the
1970s, as a region within the bone marrow containing functional cell types that can maintain …

Background: The accumulation of eosinophils into the peripheral blood and airways of
asthmatic subjects is, in part, dependent on cysteinyl leukotrienes (cysLTs). However, the …

Lipoxygenase (5-LO), a fatty acid oxygenase, is the central enzyme in leukotriene (LT)
biosynthesis, potent arachidonic acid-derived lipid mediators released by innate immune …

Stem cells are pluripotent and expected to be of benefit in the management of coronary
heart disease, stroke, diabetes mellitus, cancer, and Alzheimer's disease in which pro …