Childhood leukemia (CL) is undoubtedly caused by a multifactorial process with genetic as
well as environmental factors playing a role. But in spite of several efforts in a variety of …

Cytomegalovirus (CMV) is a ubiquitous herpesvirus that has a profound impact on the host
immune system. Congenital cytomegalovirus (cCMV) infection modulates neonatal immune …

Background: Associations between maternal tobacco exposure during pregnancy and
childhood acute lymphoblastic leukemia (ALL) have yielded mixed results. This may be due …

The development of childhood acute lymphoblastic leukemia (ALL) typically involves
formation of preleukemic clones in earlylife followed by the postnatal acquisition of “second …

AKT2 is crucial for cancer cells' invasion, metastasis, and survival. It is a possible
downstream gene target of cancer glycolysis-related microRNAs. The study investigated the …

The long-term effects of environmental pollution have been of concern as several pollutants
are carcinogenic, potentially inducing a variety of cancers, including childhood cancer …

Fine particulate matter, namely PM 2.5, increases the risk of morbidity and mortality in
various systems, including the hematopoietic and immune systems. However, there is …

Background: Tobacco smoke adversely affects the prognosis of adult cancers including
myeloid leukemia, but less is known in children. Methods: We evaluated whether pre-and …

Genome-wide association studies have identified a growing number of single nucleotide
polymorphisms (SNPs) associated with childhood acute lymphoblastic leukemia (ALL), yet …

Where people live can affect their health because of location-specific exposure to chemicals
and toxicants, lifestyle, diet, immune function development, and social and historical …