Purpose The NESARC, a “third-generation” psychiatric epidemiologic survey that integrated
detailed measures of alcohol and drug use and problems has been the data source for …

Adolescence is defined as a transitional period between childhood and adulthood
characterized by changes in social interaction and acquisition of mature cognitive abilities …

The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive
functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is …

The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …

Objective This review of the scientific literature examines the potential adult sequelae of
exposure to cannabis and related synthetic cannabinoids in adolescence. We examine the …

Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

During adolescence, both rodent and human studies have revealed dynamic changes in the
developmental trajectories of corticolimbic structures, which are known to contribute to the …

Studies using animal models of adolescent exposure to alcohol, nicotine, cannabinoids, and
the stimulants cocaine, 3, 4-methylenedioxymethampethamine and methamphetamine have …

Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …