Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations
CB Landersdorfer, JB Bulitta, M Kinzig… - Clinical …, 2009 - Springer
Antibacterials play a key role in the treatment of bone infections and appropriate surgical
prophylaxis. The rate and extent of penetration of antimicrobials into bone has been …
prophylaxis. The rate and extent of penetration of antimicrobials into bone has been …
Are population pharmacokinetic and/or pharmacodynamic models adequately evaluated? A survey of the literature from 2002 to 2004
K Brendel, C Dartois, E Comets… - Clinical …, 2007 - Springer
Abstract Model evaluation is an important issue in population analyses. We aimed to
perform a systematic review of all population pharmacokinetic and/or pharmacodynamic …
perform a systematic review of all population pharmacokinetic and/or pharmacodynamic …
[图书][B] The art of modeling
PL Bonate - 2006 - Springer
The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …
Parameter estimation in nonlinear mixed effect models using saemix, an R implementation of the SAEM algorithm
The saemix package for R provides maximum likelihood estimates of parameters in
nonlinear mixed effect models, using a modern and efficient estimation algorithm, the …
nonlinear mixed effect models, using a modern and efficient estimation algorithm, the …
Facilitation of drug evaluation in children by population methods and modelling
M Tod, V Jullien, G Pons - Clinical pharmacokinetics, 2008 - Springer
The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …
populations, the latter being particularly heterogeneous. These differences in …
Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0
Nonlinear mixed effect models (NLMEM) with multiple responses are increasingly used in
pharmacometrics, one of the main examples being the joint analysis of the pharmacokinetics …
pharmacometrics, one of the main examples being the joint analysis of the pharmacokinetics …
Further developments of the Fisher information matrix in nonlinear mixed effects models with evaluation in population pharmacokinetics
We extend the development of the expression of the Fisher information matrix in nonlinear
mixed effects models for designs evaluation. We consider the dependence of the marginal …
mixed effects models for designs evaluation. We consider the dependence of the marginal …
Clinical pharmacokinetics and pharmacodynamics of febuxostat
B Kamel, GG Graham, KM Williams, KD Pile… - Clinical …, 2017 - Springer
Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …
Design in nonlinear mixed effects models: optimization using the Fedorov–Wynn algorithm and power of the Wald test for binary covariates
We extend the methodology for designs evaluation and optimization in nonlinear mixed
effects models with an illustration of the decrease of human immunodeficiency virus viral …
effects models with an illustration of the decrease of human immunodeficiency virus viral …
[图书][B] Optimal sensor networks scheduling in identification of distributed parameter systems
M Patan - 2012 - books.google.com
Sensor networks have recently come into prominence because they hold the potential to
revolutionize a wide spectrum of both civilian and military applications. An ingenious …
revolutionize a wide spectrum of both civilian and military applications. An ingenious …