Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

The search for more effective treatments for depression is a long-standing primary objective
in both psychiatry and translational neuroscience. From initial models centered on …

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …

The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as
reward seeking and flexible decision making. However, the precise nature of its role in these …

Frontal cortex is thought to underlie many advanced cognitive capacities, from self-control to
long term planning. Reflecting these diverse demands, frontal neural activity is notoriously …

Perception of fear induced by others in danger elicits complex vicarious fear responses and
behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to …

Behavioral flexibility is the ability to adjust behavioral strategies in response to changing
environmental contingencies. A major hypothesis in the field posits that the activity of …

The prefrontal cortex (PFC) enables a staggering variety of complex behaviors, such as
planning actions, solving problems, and adapting to new situations according to external …

Opioid-based drugs are frequently used for pain management in both males and females
despite the known risk of prefrontal cortex dysfunction and cognitive impairments. Although …

The prefrontal cortex (PFC) is considered to constitute the highest stage of neural integration
and to be devoted to representation and production of actions. Studies in primates have laid …