Skeletal muscle satellite cells are considered to play a crucial role in muscle fiber
maintenance, repair and remodeling. Our knowledge of the role of satellite cells in muscle …

Myotonic dystrophy type I (DM1) is the most common form of adult muscular dystrophy,
caused by expansion of a CTG triplet repeat in the 3′ untranslated region (3′ UTR) of the …

Neuromuscular disorders are a heterogeneous group of acquired or hereditary conditions
that affect striated muscle function. The resulting decrease in muscle strength and motility …

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1
(DM1); however, the underlying molecular mechanism and the impact on the disease …

Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

ABSTRACT Myotonic dystrophy type 1 (DM1) is the most prevalent form of muscular
dystrophy in adults and yet there are currently no treatment options. Although this disease …

Muscular dystrophies and congenital myopathies arise from specific genetic mutations
causing skeletal muscle weakness that reduces quality of life. Muscle health relies on …

Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem
disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the …

The neuromuscular disease myotonic dystrophy type I (DM1) affects multiple organ systems
with the major symptoms being severe muscle weakness, progressive muscle wasting and …

ABSTRACT Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant
neuromuscular diseases caused by microsatellite expansions and belong to the family of …